This is a Windows system installed file with Windows File Protection (WFP) enabled.
ieframe.dll has 36 known versions, the most recent one is 11.00.9600.17126 (winblue_gdr_escrow.140529-2055). It is installed as an Internet Explorer extension by adding a URL search hook for web search redirection and will start when IE loads. The average file size is about 11.54 MB.
(Note, the behaviors below are for all versions of ieframe.dll, select a unique version for details.)
Located in the registry at 'SOFTWARE\Microsoft\Windows\CurrentVersion\Shell Extensions\Approved'
United States installs about 54.27% of Internet Explorer.